Nefro - 24-4 - MIOLO OK.indd

Nefro - 24-4 - MIOLO OK.indd

This is a rare renal disease characterised by steroidresistant nephrotic syndrome in the first years of life with rapid progression to end-stage renal failure. Its occurrence is usually sporadic, and it has been associated with a mutation in the Wilms tumour (WT1) suppressor gene. Recently new gene defects causing isolated diffuse mesangial sclerosis, such as LAMB2 and PLCE1 mutations, have bee...

Nefro - 24-1 MIOLO.indd

Nefro-urological mortality causes in Jerez de los Caballeros (Badajoz) in the nineteenth century.

The causes of mortality from nefro-urologic diseases in Jerez de los Caballeros (Badajoz) during the nineteenth century will be our object of study. We have analyzed the death registry books of the parishes in Jerez. The percentage of deaths from nefro-urologic diseases compared to other pathologies is 0.8%, being most affected males in age ranges from 25-34 and 65-75 years of age. The months w...

Nefro - 22-4.indd

The uraemic syndrome is a complex mixture of organ dysfunctions attributed to the retention of a myriad of compounds that under normal conditions are excreted by healthy kidneys. While recent years have seen major steps in the identification and characterisation of uraemic retention solutes and in the knowledge of their patho-physiological importance, this knowledge remains far from complete. T...

Nefro - 26-4 - MIOLO.indd

The clinical relevance: The assessment of the antigenicity of an injectable molecule for the human organism requires human patient sera due to the inherent variability of antibodies from person to person, and the inherent variation of bioactivity of antibodies within a single individual. Antibodies produced experimentally in animals give little information with regard to clinical effects of the...